Iridoids with anti-inflammatory activity from Vitex peduncularis.
نویسندگان
چکیده
A new iridoid, pedunculariside, together with the known iridoid agnuside were isolated from the butanol extract of Vitex peduncularis stem bark. Both pedunculariside and agnuside showed preferential inhibition of COX-2, with IC50 values of 0.15 +/- 0.21 mg/ml and 0.026 +/- 0.015 mg/ml respectively, while having only small inhibitory effects on COX-1. Both compounds did not exhibit cytotoxicity against vero cells.
منابع مشابه
Pharmacological and Phytochemical Evidences for the Extracts from Plants of the Genus Vitex – A Review
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متن کاملVitex Peduncularis in the Treatment of Blackwater Fever
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ورودعنوان ژورنال:
- Planta medica
دوره 68 1 شماره
صفحات -
تاریخ انتشار 2002